Table of Contents

Introduction. 3

Part 1. HIV-Associated Tuberculosis. 5

Part 2. Treatment Options for HIV-Associated Tuberculosis. 7

Results. 10

References. 11

Glossary. 12

Appendix. 17


Фрагмент работы:

The aim of the paper was to consider the essence of HIV-associated TB and outline the existing treatment options for HIV-Associated Tuberculosis. Having analyzed the publications on the topic, we came to the following conclusions.

The HIV-associated TB epidemic is a major challenge to international public health, remaining the most important opportunistic infection in people living with HIV globally and accounting for nearly 0.5 million deaths each year. However, over the past 10 years, major progress has been achieved in defining guidelines for the optimum case management with a combination of co-trimoxazole prophylaxis, optimally timed ART, and diagnosis and appropriate supportive care for treatment complications including drug toxicity and IRIS. The major remaining challenges are the management of TB in the increasing proportion of patients receiving PI-containing ART and the management of drug resistant TB. Having defined case management strategies, the ongoing challenge is to further develop effective, comprehensive and sustainable means of delivery through health systems.

HIV-associated pulmonary TB mandates a committed approach that encompasses both effective as well as enduring therapy originating from newer drug combinations, evolving ideas and emerging concepts from clinical trials globally, which if implemented in a proper and coordinated manner could not only save millions of lives but also offer a better quality of life to patients suffering from this coinfection.

The aim of TB treatment is to achieve cure, to prevent death and relapse, and to render patients noninfectious as rapidly as possible, as well as to prevent the emergence of drug resistance. Anti-TB agents are, therefore, selected (1) to kill the actively metabolizing bacilli in the cavities, (2) to destroy less actively replicating bacilli in the acidic and anoxic closed lesions, and (3) to kill near-dormant bacilli that might otherwise cause a relapse of the disease. The most effective agents for the destruction of tubercle bacilli in the 3 categories described above are, respectively, isoniazid, pyrazinamide, and rifampin.

Список использованной литературы:

American Thoracic Society, Centers for Disease Control and Prevention, Infectious Diseases Society of America. Treatment of tuberculosis. Am J Respir Crit Care Med. 2003;167:603–662. reprinted in MMWR Recomm Rep 2003; 52(RR-11):1–77 Gopalan, N., Chandrasekaran, P., Swaminathan, S., & Tripathy, S. (2016). Current trends and intricacies in the management of HIV-associated pulmonary tuberculosis. AIDS Research and Therapy, 13, 34.  Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review // Stephen D Lawn, Graeme Meintjes, Helen McIlleron, Anthony D Harries, Robin Wood BMC Med. 2013 [Electronic Resource]. – Mode of access:  Date of access: 28.04.2018 Mitchison D.A. Hypothesis: the action of anti-tuberculosis drugs in short course chemotherapy. Tubercle. 1985;66:219–225. Mitchison D.A. The role of individual drugs in the chemotherapy of tuberculosis. Int J Tuberc Lung Dis. 2000;4:796–806. Treatment Options for HIV-Associated Tuberculosis / Philip Chukwuka Onyebujoh, Isabela Ribeiro, Christopher Curtis Whalen // Infect Dis. Author manuscript; available in PMC 2010 Apr 27 [Electronic Resource]. – Mode of access:  – Date of access: 28.04.2018 World Health Organization (WHO) Geneva: WHO; 2002. An expanded DOTS framework for effective tuberculosis control. WHO/CDS/TB/2002.297. World Health Organization (WHO) Treatment of tuberculosis: guidelines for national programmes. 3rd ed. WHO/CDS/TB/2003.313. Geneva: WHO; 2003. [Electronic Resource]. – Mode of access:  Date of access: 28.04.2018

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